TITLE:
Dietary Modification of Lower Urinary Tract Symptoms with Fermented Whey Product
AUTHORS:
Tiiu Kullisaar, Silver Türk, Margus Punab, Andre Veskioja, Epp Songisepp, Kersti Zilmer, Mihkel Zilmer
KEYWORDS:
Lower Urinary Tract Symptoms (LUTS); Benign Prostatic Hypertrophy (BPH); Prostate; Fermented Whey Product (FWP); Oxidative Stress
JOURNAL NAME:
Open Journal of Urology,
Vol.3 No.2,
May
17,
2013
ABSTRACT: After the age of 50, the prostate begins to increase in
size. This is known as benign prostatic hypertrophy (BPH). Compression
of urethra by enlarged prostate causes dribbling reduced force of the urinary
stream, pain and occasional bleeding or infection. This causes difficulty in
urinating and requires many men to get up several times during the night to
urinate. The aim of our study was to evaluate an influence of new fermented
whey based product (FWP) to several biochemical parameters and lower urinary
tract symptoms (LUTS). Patients from the outpatient department of Andrology
Center were randomized. This study involved the patients with minor to moderate
LUTS, International Prostate Symptoms Score (IPSS) range 3 - 19 but
not prostatitis (NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) 4 and
2-glass test negative for prostate inflammation and infection). Consumption of
the FWP decreased the IPSS score in patients with moderate LUTS/BPH (p 0.001)
whereas irritative and obstructive symptoms changed in parallel. There was a
correlation between LUTS symptoms change and level of inflammation- and
oxidative stress-related indices (blood high-sensitive C-reactive protein,
hsCRP; glycated haemoglobin, HbA1c;
oxidized low density lipoprotein, oxLDL; interleukine-10, IL-10 and
8-isoprostanes in the urine). Statistically significant changes in mentioned parameters
occurred only in study group. Compression of urethra by enlarged prostate
explains LUTS in BPH patients. Elevated oxidative stress (OxS) intensifies peroxidation
of cell membrane phospholipids. This generates 8-isoprostanes (8-EPI), the
prostaglandin-like compounds that can exaggerate LUTS. 8-isoprostanes may cause
constriction of bladder and urethra in nanomolar concentrations. Consuming
the whey-based product fermented by special lactobacilli strains may improve
LUTS as well as OxS and diminish LUTS-related inflammatory response.