TITLE:
Comparison of Lipid Peroxidation and Anti-Oxidant Ac-tivities in Pre-Eclamptic & Normal Pregnancies in Nigerian Population
AUTHORS:
Adetunji O. Adeniji, Dolapo P. Oparinde
KEYWORDS:
Lipid Peroxidation; Anti-Oxidant Status; Preeclampsia; Malondialdehyde
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.4 No.5,
May
16,
2013
ABSTRACT: Purpose: To
compare the serum malondialdehyde (MDA) and total antioxidant status in women
with preeclampsia and normal pregnancy in our environment. Materials & Methods: This was a 3-year,
cross-sectional, case control study of 100 preeclamptic and
200 normotensive pregnant women at Ladoke Akintola University of Technology
(LAUTECH) Teaching Hospital, Osogbo, Nigeria. The study protocol was reviewed
and approved by our Institutional Ethical Review
Committee and all participants gave their consent. The
fasting serum of recruited patients were analysed for Malondialdehyde (MDA)
with rapid, sensitive and specific Thiobarbituric Acid (TBA) assay, while the
Total Antioxidant status (TAS) was determined using the capacity
of the biological fluids to inhibit the production of thiobarbituric acid reactive substances (TBARS) from sodium
benzoate under the influence of the free oxygen radicals derived from Fenton’s reaction. Results: The
mean serum MDA was significantly higher in the preeclamptic group (2.96 nmol/ mL) than the value recorded (1.23 nmol/mL) in the control group (P =
0.0001). Conversely, significantly lower mean TAS (0.46 nmol/mL vs 0.62 nmol/mL) was noticed in the preeclamptic group (P = 0.0001). Conclusion: The study showed significant increase in lipid
peroxidation and failure of compensatory antioxidant functions in preeclamptic
pregnant Nigerian women.