TITLE:
Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy
AUTHORS:
Dotun Ogunyemi, Jun Xu, Arnold M. Mahesan, Steve Rad, Eric Kim, Jacqueline Yano, Carolyn Alexander, Jerome I. Rotter, Y.-D. Ida Chen
KEYWORDS:
Adipose Tissue; Pregnancy; Adipocytokine Pathway; Insulin Resistance
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.3 No.2,
May
16,
2013
ABSTRACT: Objective: To profile
the differential gene expression of the KEGG Adipocytokine Signaling pathway
in omental compared to subcutaneous tissue in normal pregnancy. Study Design:
Subjects included 14 nonobese, normal glucose tolerant, healthy pregnant
women. Matched omental and subcutaneous tissue were obtained at elective
cesarean delivery. Gene expression was evaluated using microarray and validated
by RT-PCR. Differential gene expression was defined as ≥1.5 fold increase at p