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Rung, J., Cauchi, S., Albrechtsen, A., Shen, L., Rocheleau, G., Cavalcanti-Proenca, C., et al. (2009) Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance, and hyperinsulinemia. Nature Genetics, 41, 1110-1115. doi:10.1038/ng1009-1156c

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• TITLE: Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy

  AUTHORS: Dotun Ogunyemi, Jun Xu, Arnold M. Mahesan, Steve Rad, Eric Kim, Jacqueline Yano, Carolyn Alexander, Jerome I. Rotter, Y.-D. Ida Chen

  KEYWORDS: Adipose Tissue; Pregnancy; Adipocytokine Pathway; Insulin Resistance

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.3 No.2, May 16, 2013

  ABSTRACT: Objective: To profile the differential gene expression of the KEGG Adipocytokine Signaling pathway in omental compared to subcutaneous tissue in normal pregnancy. Study Design: Subjects included 14 nonobese, normal glucose tolerant, healthy pregnant women. Matched omental and subcutaneous tissue were obtained at elective cesarean delivery. Gene expression was evaluated using microarray and validated by RT-PCR. Differential gene expression was defined as ≥1.5 fold increase at p