TITLE:
Determination of Mitochondrial Functional State in Vital Tissues by Cytobiochemical Analysis of Peripheral Blood Lymphocytes
AUTHORS:
Galina A. Frelikh, Elena A. Yanovskaya, Natalia Yu. Polomeeva, Maxim S. Timofeev, Vladimir A. Slepichev, Olga S. Bryushinina, Yulia G. Zyuz’kova, Roman V. Gurto, Alexander S. Vasil’ev, Elena V. Semiglazova, Vladimir V. Udut
KEYWORDS:
Mitochondria; Energy Metabolism; Lymphocyte; Succinate Dehydrogenase; Cytobiochemical
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.3 No.2A,
May
16,
2013
ABSTRACT: In the work, we offer a brief report by
research results demonstrating correlations between energy status of peripheral
blood lymphocytes and functional state of vital tissues mitochondria. Basing on
our preliminary data, showing correlations between succinate dehydrogenase
(SDH) activity in peripheral blood lymphocytes and speed or duration of pyridine
nucleotides reduction in mitochondria of rat brain and liver tissues, we
propose an idea of using cytobiochemical method of SDH estimation in peripheral
blood lymphocytes for evaluation of tissue mitochondria status. The method could
be successfully used in clinical practice for early revealing of energy
metabolism disturbances that allows preventing disease development and
optimizing the diseases therapy.