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M. C. Kowala, J. J. Nunnari, S. K. Durham and R. J. Nicolosi, “Doxazosin and Cholestyramine Similarly Decrease Fatty Streak Formation in the Aortic Arch of Hyper-Lipidemic Hamsters,” Atherosclerosis, Vol. 91, No. 1, 1991, pp. 35-49. doi:10.1016/0021-9150(91)90185-6

has been cited by the following article:

• TITLE: β-Glucan Fiber from Spent Brewer’s Yeast Reduces Early Atherosclerosis Greater Than Psyllium in Hypercholesterolemic Syrian Golden Hamsters

  AUTHORS: Thomas A. Wilson, Damian A. Barbato, Robert J. Nicolosi

  KEYWORDS: β-Glucan Fiber; Plasma Cholesterol; Aortic Fatty Streak; Psyllium; Hamsters

  JOURNAL NAME: Food and Nutrition Sciences, Vol.4 No.5, May 15, 2013

  ABSTRACT: β-Glucans, mostly from oats, have been shown to reduce blood concentrations of total and LDL-cholesterol in animals and humans. After processing, spent brewer’s yeast, a by-product of the fermentation process, contains 85% - 90% β-glucans. The purpose of this study was to evaluate the effect of yeast-derived β-glucan fiber on plasma lipids and early atherosclerosis development in hamsters consuming a semi-purified hypercholesterolemic diet (HCD). Animals were fed either the HCD or the HCD containing psyllium or β-glucan fiber from yeast for 12 weeks. Both the psyllium and β-glucan fiber from yeast showed significant decreases in plasma total cholesterol, non-HDL-C, triacylglycerol, and aortic fatty streak area when compared to the HCD. Also, the β-glucan fiber from yeast had significantly less aortic fatty streak area compared to the psyllium diet. Findings from this study show that while both β-glucan fiber from yeast and psyllium produced similar reductions in plasma lipid and lipoprotein concentrations, the β-glucan fiber from yeast prevented the development early atherosclerosis better than psyllium in the hamsters.