TITLE:
Anaplastic Lymphoma Kinase (ALK) and p53 Are Potentially Useful Markers to Distinguish Inflammatory Myofibroblastic Tumor
AUTHORS:
Shinji Kurosaka, Kazumasa Matsumoto, Akira Irie, Takahiro Hirayama, Morihiro Nishi, Tetsuo Fujita, Takefumi Satoh, Yuichi Sato, Masatsugu Iwamura, Kazunari Yoshida
KEYWORDS:
Inflammatory Myofibroblastic Tumor; Immunohistochemistry; Bladder Cancer; Anaplastic Lymphoma Kinase; p53
JOURNAL NAME:
Open Journal of Urology,
Vol.3 No.2,
May
15,
2013
ABSTRACT: Aims: Inflammatory myofibroblastic tumor
(IMT) of the urinary bladder is a clinically and histologically uncommon benign
tumor that can be easily mistaken for a malignant neoplasm. We sought to
determine whether immunohistochemical staining would be evaluated IMT of
the urinary bladder. We have also shown the literatures that imminohistochemical
staining of IMT was investigated to distinguish malignant lesions using PubMed
data base. Methods: Immunohistochemical staining, including anaplastic lymphoma kinase
(ALK), p53, cytokeratin, vimentin, desmin, alpha-smooth muscle actin,
myoglobin, smooth muscle myosin and S100, was carried out on serial sections
from archival specimens of three patients who underwent transurethral resection
and partial cystectomy. Results: Immunohistchemical
staining in all patients was positive for ALK and weak positive for p53
protein. In the literatures, positive rates of ALK and p53 inthe IMT of the urinary bladder were 60.9% and
53.1%, respectively. Sarcoma and carcinosarcoma were shown in the pathological
specimens with negative ALK and strongly positive p53 inthe same data base. Conclusions: Both ALK and p53 were potentially useful protein markers to
distinguish between IMT and sarcoma. However, this study was small sample size.
Further study was warranted an investigation of the availability of these
proteins in IMT.