TITLE:
Parental Consanguinity in Infertile Males
AUTHORS:
Abdullah Demirtas, Emre Can Akinsal, Oguz Ekmekcioglu
KEYWORDS:
Azoospermia; Genetics; Male Infertility; Parental Consanguinity
JOURNAL NAME:
Open Journal of Urology,
Vol.3 No.2,
May
15,
2013
ABSTRACT: This study was investigated whether parental
consanguinity in males has an effect on or relationship with some infertile
subgroups and some semen and hormone parameters. The charts of 2651 infertile
males were evaluated retrospectively for parental consanguinity ratios,
sperm counts, motility parameters and hormonal values from the records of 2651
infertile males. In 1260 eligible males the first cousin parental consanguinity
ratio was 22.6%. In 119 males with nonobstructive azoospermic (NOA) and 430
males with normal sperm counts, the ratios were 34.5% and 20.9%, respectively
(p = 0.002). In the NOA group the parental consanguinity ratios were
27.1% (23/85) and 52.9% (18/34) in males with FSH values of >7.6 and 7.6
mIU/ml, respectively (p = 0.007). In males with normal sperm counts if
the parents were first cousins, both sperm counts and motility parameters were
significantly reduced when compared with the others. To our knowledge, this is
the first study of consanguinity ratios among some infertile subgroups. In
males with parental consanguinity lower sperm counts and motility ratios in
normozoospermic males and lower FSH levels in the NOA group might show a
relation with some genetically transmitted defects.