TITLE:
Intrauterine transplantation of autologous bone marrow derived mesenchymal stem cells followed by conception in a patient of severe intrauterine adhesions
AUTHORS:
Yong Zhao, Aiming Wang, Xiaorong Tang, Min Li, Ling Yan, Wei Shang, Meizhu Gao
KEYWORDS:
Intrauterine Adhesions; Asherman’s Syndrome; Bone Marrow Derived Mesenchymal Stem Cells; Pregnancy
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.3 No.3,
May
15,
2013
ABSTRACT: On
a woman with severe intrauterine adhesions, hysteroscopy followed by cyclical
hormone replacement therapy was tried for 5 months, for development of the
endometrium. When this failed, autologous stem cells were tried as an
alternative therapy. Adult autologous bone marrow mesenchymal stem cells isolated
from patient’s own bone marrow and were cultured and placed in the
endometrial cavity under ultrasound guidance after curettage. Patient was
then given cyclical hormonal therapy. Endometrium was assessed intermittently
using ultrasound. Three months later, endometrium partly recovered with
improved ultrasonic echo. This resulted in spontaneous pregnancy followed by
confirmation of gestational sac, yolk sac, and primitive heart tube pulse on
ultrasound. Autologous bone marrow derived mesenchymal stem cells could
regenerate injured endometrium not responding to conventional treatment and
can be used as an alternative in females with severe Asherman’s syndrome.