TITLE:
Lead induced overactivation of phagocytes and variation in enzymatic and non-enzymatic antioxidant defenses in intestinal macrophages of Channa punctatus
AUTHORS:
Nilantika Paul, Mahuya Sengupta
KEYWORDS:
Lead; Channa punctatus; Antioxidant; Oxidative Stress; Lipid Peroxidation; Respiratory Burst; Glutathione; Bioaccumulation
JOURNAL NAME:
Modern Research in Inflammation,
Vol.2 No.2,
May
9,
2013
ABSTRACT: The aim of this study
is to assess the adverse effects of lead, a well-documented non-essential
element that occurs naturally in the
environment, on Channa punctatus,
in relation with ROS production and oxidative
stress. Fishes were sampled, acclimatized and kept treated or untreated
with lead (9.43 mg/L) under observation for 4 days. At day 4, respiratory burst
activity, lipid peroxidation activity and superoxide
dismutase level increased significantly in treated group as compared to the
control. On the contrary, catalase, glutathione S-transferase, glutathione peroxidase, glutathione reductase and reduced glutathione
activity decreased on treatment with lead. These results suggest that heavy
metal like lead induces oxidative stress, influences the antioxidant defense system and may lead to physiological disorders
rendering the health and survival of exposed fish to a compromised
state.