TITLE:
The relation of flow-mediated vasodilatation and diastolic function in uncomplicated Type 2 diabetic patients
AUTHORS:
J. Charvat, J. Chlumsky, P. Svab, M. Peckova
KEYWORDS:
Flow-Mediated Vasodilatation; Tissue and Pulse Doppler Echocardiography; Type 2 Diabetes Mellitus; Diastolic Function; Left Ventricular Relaxation
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.3 No.2,
May
9,
2013
ABSTRACT: Objectives: To evaluate the
association of diastolic function of the left ventricle with flowme-diated
dilatation (FMD) in uncomplicated Type 2 diabetes mellitus patients. Methods: Eighty-two uncomplicated Type
2 diabetic patients were examined by pulse and tissue Doppler echocardiography
and FMD of brachial artery. The patients were divided into 2 groups according
to the size of the left ventricular relaxation parameter—E’. Results: The average
age of the patients was 61 ± 6
years. FMD was 5.0 ± 1.8% in 41
patients with E’ from 3 to 7.4 cm/s (mean 6 cm/s) comparing to 5.1 ± 1.9% (p = 0.96) in 41 patients
with E’ from 7.5 to 10.9 cm/s (mean 8.9 cm/s). E/E’ was 11.2 ± 2.3 in the group with lower E’ and 9.1 ± 1.6
in the group with higher E’ (p 0.001).
Linear negative correlation was found between E/E’ and FMD for the patients
with E’ from 3 to 7.4 cm/s (R2 = 0.131; p = 0.025) but not for
the group of patients with the higher E’. The significant
association between FMD and E/E’ was confirmed by multivariate analysis ((Rc)2 = 0.233; p 0.05). Conclusion: FMD has no impact on the left ventricular relaxation. However FMD is
negatively associated with E/E’ in Type 2 diabetic patients who have low E’
as a sign of an impaired early relaxation.