TITLE:
Management of cervical intraepithelial neoplasia in Japanese pregnant women
AUTHORS:
Yuko Matsubara, Toru Fujioka, Hisashi Hashimoto, Katsuyuki Hamada, Keiichi Matsubara, Akihiro Nawa
KEYWORDS:
Cervical Intraepithelial Neoplasia; Prenancy
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.3 No.3,
May
8,
2013
ABSTRACT: Objective:
In this study, we evaluated the management of cervical intraepithelial
neoplasia (CIN) in pregnant women and evaluated the postpartum prognosis.
Methods: Twenty-four pregnant women, who were diagnosed with CIN at Ehime
University Hospital between January 2008 and October 2012, were recruited. The
mode of delivery and pathophysiological examination results in the postpartum
period were evaluated. Results: Four patients were antenatally diagnosed with
either CIN1 or CIN2. Of these patients, CIN regressed or remained stable during
pregnancy, and there was no disease progression in the postpartum period.
Nine patients were diagnosed with severe dysplasia (CIN3) and eleven patients
had carcinoma in situ (CIS). Of these
patients, 5/9 (55%) and 4/11 (36%), respectively, had disease regression
postnatally. No CIN lesion progressed to invasive carcinoma after delivery. Conclusions: We determined that many cases diagnosed antenatally with CIN regressed
during the postpartum period, regardless of the grade of CIN. We recommend a
conservative management strategy with careful ante- and postpartum
examinations for pregnant women with CIN.