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Ueda, Y., Enomoto, T., Miyatake, T., Yoshino, K., Fujita, M., Miyake, T., Fujiwara, K., Muraji, M., Kanagawa, T. and Kimura, T. (2009) Postpartum outcome of cervical intraepithelial neoplasia in pregnant women determined by route of delivery. Reproductive Sciences, 16, 1034-1039. doi:10.1177/1933719109339349

has been cited by the following article:

• TITLE: Management of cervical intraepithelial neoplasia in Japanese pregnant women

  AUTHORS: Yuko Matsubara, Toru Fujioka, Hisashi Hashimoto, Katsuyuki Hamada, Keiichi Matsubara, Akihiro Nawa

  KEYWORDS: Cervical Intraepithelial Neoplasia; Prenancy

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.3 No.3, May 8, 2013

  ABSTRACT: Objective: In this study, we evaluated the management of cervical intraepithelial neoplasia (CIN) in pregnant women and evaluated the postpartum prognosis. Methods: Twenty-four pregnant women, who were diagnosed with CIN at Ehime University Hospital between January 2008 and October 2012, were recruited. The mode of delivery and pathophysiological examination results in the postpartum period were evaluated. Results: Four patients were antenatally diagnosed with either CIN1 or CIN2. Of these patients, CIN regressed or remained stable during pregnancy, and there was no disease progression in the postpartum period. Nine patients were diagnosed with severe dysplasia (CIN3) and eleven patients had carcinoma in situ (CIS). Of these patients, 5/9 (55%) and 4/11 (36%), respectively, had disease regression postnatally. No CIN lesion progressed to invasive carcinoma after delivery. Conclusions: We determined that many cases diagnosed antenatally with CIN regressed during the postpartum period, regardless of the grade of CIN. We recommend a conservative management strategy with careful ante- and postpartum examinations for pregnant women with CIN.