TITLE:
Local Drug Delivery Strategy for Cancer Treatment: Use of Biocompatible Sol-Gel-Derived Porous Materials
AUTHORS:
Odile Cristini-Robbe, Florian Ruyffelaere, Florent Dubart, Ange Uwimanimpaye, Christophe Kinowski, Remy Bernard, Catherine Robbe-Masselot, Ikram El Yazidi, Sylvia Turrell
KEYWORDS:
Sol-Gel; Micro-Raman; Post-Doping; Chemotherapy; Silica Gels; Drug-Release Agents
JOURNAL NAME:
New Journal of Glass and Ceramics,
Vol.3 No.2,
April
30,
2013
ABSTRACT: Porous silica xerogel materials have
been developed to use as drug-release agents to be implanted directly in or
near cancerous tissues. In order to test the capacity of the materials to
absorb and then to release medicinal substances, a battery of examinations (UV
and visible micro-Raman, porosity measurements, UV-visible absorption spectra)
have been made using test drug molecules (clotrimazole, primaquine diphosphate
and the anti-cancer agent vinblastine sulphate). Results show that the
molecules can be post-doped into the gels and the Raman data provide
indications of the best conditions for detecting the substances absorbed in the
gels. Spectroscopic results show that the drug molecules are released by the
xerogel over a period of 10 days. These results are promising for the
development of these materials as drug-release agents.