M. S. Karlan, L. L. Hench, M. Madden and M. Ogino, “A Bone-Bonding Bioactive Material Implant in the Head and Neck: Bioglass,” Surgical Forum, Vol. 39, 1979, pp. 575-577.
has been cited by the following article:
TITLE: Chronology of Bioactive Glass Development and Clinical Applications
AUTHORS: Larry L. Hench
KEYWORDS: Bioactive Glass; 45S5 Bioglass; Hydroxyl-Carbonate Apatite (HCA); Bone-Bonding; Osteogenesis; Regeneration; Genes, Dental; ENT; Maxillo-Facial; Orthopedics; Clinical; Osteostimulation
JOURNAL NAME: New Journal of Glass and Ceramics, Vol.3 No.2, April 30, 2013
ABSTRACT: The key research and development steps for bioactive glass (45S5 Bioglass) are documented from the date of discovery in 1969 through FDA approvals of the first dental, ENT, maxillo-facial and orthopedic clinical products. Understanding the mechanisms and quantifying the rapid surface reactions to form a bone-bonding hydroxyl-carbonate apatite (HCA) layer on the bioactive glass in contact with living bone was a vital part of the early development of this class of biomaterials. A key later discovery was enhanced osteogenesis and in situ bone regeneration by controlled release of ionic dissolution products from the bioactive glass particulates that leads to up-regulation and activation of seven families of genes, a process called osteostimulation.