Article citationsMore>>

I. D. Xynos, A. J. Edgar, L. D. K. Buttery, L. L. Hench and J. M. Polak, “Gene Expression Profiling of Human Osteoblasts Following Treatment with the Ionic Dissolution Products of Bioglass® 45S5 Dissolution,” Journal of Biomedical Materials Research, Vol. 55, No. 2, 2001, pp. 151-157. doi:10.1002/1097-4636(200105)55:2<151::AID-JBM1001>3.0.CO;2-D

has been cited by the following article:

• TITLE: Chronology of Bioactive Glass Development and Clinical Applications

  AUTHORS: Larry L. Hench

  KEYWORDS: Bioactive Glass; 45S5 Bioglass; Hydroxyl-Carbonate Apatite (HCA); Bone-Bonding; Osteogenesis; Regeneration; Genes, Dental; ENT; Maxillo-Facial; Orthopedics; Clinical; Osteostimulation

  JOURNAL NAME: New Journal of Glass and Ceramics, Vol.3 No.2, April 30, 2013

  ABSTRACT: The key research and development steps for bioactive glass (45S5 Bioglass) are documented from the date of discovery in 1969 through FDA approvals of the first dental, ENT, maxillo-facial and orthopedic clinical products. Understanding the mechanisms and quantifying the rapid surface reactions to form a bone-bonding hydroxyl-carbonate apatite (HCA) layer on the bioactive glass in contact with living bone was a vital part of the early development of this class of biomaterials. A key later discovery was enhanced osteogenesis and in situ bone regeneration by controlled release of ionic dissolution products from the bioactive glass particulates that leads to up-regulation and activation of seven families of genes, a process called osteostimulation.