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I. D. Xynos, M. V. J. Hukkanen, J. J. Batten, I. D. Buttery, L. L. Hench and J. M. Polak, “Bioglass® 45S5 Stimulates Osteoblast Turnover and Enhances Bone Formation in Vitro: Implications and Applications for Bone Tissue Engineering,” Calcified Tissue International, Vol. 67, No. 4, 2000, pp. 321-329. doi:10.1007/s002230001134

has been cited by the following article:

• TITLE: Chronology of Bioactive Glass Development and Clinical Applications

  AUTHORS: Larry L. Hench

  KEYWORDS: Bioactive Glass; 45S5 Bioglass; Hydroxyl-Carbonate Apatite (HCA); Bone-Bonding; Osteogenesis; Regeneration; Genes, Dental; ENT; Maxillo-Facial; Orthopedics; Clinical; Osteostimulation

  JOURNAL NAME: New Journal of Glass and Ceramics, Vol.3 No.2, April 30, 2013

  ABSTRACT: The key research and development steps for bioactive glass (45S5 Bioglass) are documented from the date of discovery in 1969 through FDA approvals of the first dental, ENT, maxillo-facial and orthopedic clinical products. Understanding the mechanisms and quantifying the rapid surface reactions to form a bone-bonding hydroxyl-carbonate apatite (HCA) layer on the bioactive glass in contact with living bone was a vital part of the early development of this class of biomaterials. A key later discovery was enhanced osteogenesis and in situ bone regeneration by controlled release of ionic dissolution products from the bioactive glass particulates that leads to up-regulation and activation of seven families of genes, a process called osteostimulation.