TITLE:
Chronology of Bioactive Glass Development and Clinical Applications
AUTHORS:
Larry L. Hench
KEYWORDS:
Bioactive Glass; 45S5 Bioglass; Hydroxyl-Carbonate Apatite (HCA); Bone-Bonding; Osteogenesis; Regeneration; Genes, Dental; ENT; Maxillo-Facial; Orthopedics; Clinical; Osteostimulation
JOURNAL NAME:
New Journal of Glass and Ceramics,
Vol.3 No.2,
April
30,
2013
ABSTRACT: The key research and development steps
for bioactive glass (45S5 Bioglass) are documented from the date of discovery
in 1969 through FDA approvals of the first dental, ENT, maxillo-facial and
orthopedic clinical products. Understanding the mechanisms and quantifying the
rapid surface reactions to form a bone-bonding hydroxyl-carbonate apatite (HCA)
layer on the bioactive glass in contact with living bone was a vital part of
the early development of this class of biomaterials. A key later discovery was
enhanced osteogenesis and in situ bone regeneration by controlled release of ionic dissolution products from the
bioactive glass particulates that leads to up-regulation and activation of seven
families of genes, a process called osteostimulation.