TITLE:
Clinical applications of molecular profiling in colorectal cancer: Review of the literature
AUTHORS:
Elrasheid A. H. Kheirelseid, Nicola Miller, Michael J. Kerin
KEYWORDS:
Molecular Profiling in Colorectal Cancer; Gene Expression in Colorectal Cancer; Colorectal Cancer Genetics; Colorectal Cancer
JOURNAL NAME:
American Journal of Molecular Biology,
Vol.3 No.2,
April
30,
2013
ABSTRACT: Despite the developments in the diagnostic and management strategies, a considerable number
of colorectal cancer (CRC) patients
present with disease recurrence after curative surgery. Moreover; there are no
reliable indicators to determine the prognosis and response of CRC patients to
therapy. By harnessing recent
technological advances in molecular profiling techniques, it is anticipated
that greater insight to the various
combinations of genetic events or alternative pathways underlying
carcinogenesis will be gained. By carrying out literature search, we were able
to identify a comprehensive list of genes with high differential expression patterns in colorectal cancer that
could serve as molecular markers to complement existing histopathological factors in diagnosis, follow up and
therapeutic strategies for individualized care of patients.