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Del Rio, M., Molina, F., Mollevi, C.B., et al. (2007) Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan. Journal of Clinical Oncology, 25, 773-780. doi:10.1200/JCO.2006.07.4187

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• TITLE: Clinical applications of molecular profiling in colorectal cancer: Review of the literature

  AUTHORS: Elrasheid A. H. Kheirelseid, Nicola Miller, Michael J. Kerin

  KEYWORDS: Molecular Profiling in Colorectal Cancer; Gene Expression in Colorectal Cancer; Colorectal Cancer Genetics; Colorectal Cancer

  JOURNAL NAME: American Journal of Molecular Biology, Vol.3 No.2, April 30, 2013

  ABSTRACT: Despite the developments in the diagnostic and management strategies, a considerable number of colorectal cancer (CRC) patients present with disease recurrence after curative surgery. Moreover; there are no reliable indicators to determine the prognosis and response of CRC patients to therapy. By harnessing recent technological advances in molecular profiling techniques, it is anticipated that greater insight to the various combinations of genetic events or alternative pathways underlying carcinogenesis will be gained. By carrying out literature search, we were able to identify a comprehensive list of genes with high differential expression patterns in colorectal cancer that could serve as molecular markers to complement existing histopathological factors in diagnosis, follow up and therapeutic strategies for individualized care of patients.