TITLE:
Cancer induction pathways and HF-EMF irradiation
AUTHORS:
Gérard Ledoigt, Dominique Belpomme
KEYWORDS:
Cell Membrane; Chronic Inflammation; EMF Exposure; Gene Expression; Cancer; Carcinogenesis; NF-κB
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.3 No.2,
April
30,
2013
ABSTRACT: The response of cells to different types of electromagnetic fields can be induced by low-level (athermal) high frequency (HF)
electromagnetic field (EMF) exposure associated with mobile phone technologies. There are many examples of
biological effects involving the epigenome. EMF could trigger protein activation mediated by
ligands, such as Ca2+, that alter the conformation of binding
proteins, especially the NADPH plasmic membrane oxidase, so inducing increased
formation of reactive oxygen species (ROS) that may alter proteomic functions.
Classical antiapoptotic and procarcinogenic signaling
mechanisms that are commonly found activated in human malignancies and in
inflammation mainly involve the transcription factor NF-κB. The microenvironment that exists
during chronic inflammation can contribute to cancer progression. The data
support the proposition that long term HF-EMF exposure caused by improper use
of cell phones may potentially cause cancer.