TITLE:
Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives
AUTHORS:
Dongping Shao, Yanbing Yang, Fei Xue, Xianjin Luo, Reyila Wubulikasimu, Yuhuan Li, Rongmei Gao, Weidong Ye
KEYWORDS:
1, 2, 4-Triazole; Anti-Enterovirus; Coxsackie B Viruses
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.3 No.1A,
April
30,
2013
ABSTRACT: A series of 1,2,4-triazole
derivatives were synthesized, and their abilities to inhibit the in vitro
replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole
derivatives, compound 3 g displayed potent activity, with a high antiviral
potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new
synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental
analyses.