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G. Pürstinger, “Synthesis and Anti-CVB 3 Evaluation of Substituted 5-Nitro-2-Phenoxybenzonitriles,” Bioorganic & Medicinal Chemistry Letters, Vol. 18, No. 18, 2008, pp. 5123-5125. doi:10.1016/j.bmcl.2008.07.099

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• TITLE: Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives

  AUTHORS: Dongping Shao, Yanbing Yang, Fei Xue, Xianjin Luo, Reyila Wubulikasimu, Yuhuan Li, Rongmei Gao, Weidong Ye

  KEYWORDS: 1, 2, 4-Triazole; Anti-Enterovirus; Coxsackie B Viruses

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.1A, April 30, 2013

  ABSTRACT: A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.