Article citationsMore>>

Z. X. Liu, Y. R. Yi, J. L. Zhao and M. X. Tang, “SolidPhase Synthesis of 4,5-Disubstituted-1,2,4-Triazole-3-Thione Derivatives Based on the Resin-Bound Acylhydrazines,” Synthetic Communications, Vol. 42, No. 1, 2012, pp. 5561. doi:10.1080/00397911.2010.521609

has been cited by the following article:

• TITLE: Solid Phase Synthesis of 3,4,5-Trisubstituted-1,2,4-Triazoles Derivatives from the Resin-Bound Acylhydrazines

  AUTHORS: Rongjian Xie, Xingang Liu, Chao Mai, Zhanxiang Liu

  KEYWORDS: Resin-Bound Acylhydrazine; Solid-Phase Synthesis; 1, 2, 4-Triazoles

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.1A, April 30, 2013

  ABSTRACT: An extension of our methodology on solid-phase synthesis of 3,4,5-trisubstituted-1,2,4-triazoles under mild conditions has been developed. Firstly, the resin-bound acylhydrazine is reacted with orthoesters to provide resin-bound 1,3,4-oxadiazoles. Secondly, condensation of 1,3,4-oxadiazoles resin with the corresponding arylamines hydrochloride to form the the resin-bound triazoles. 3,4,5-Trisubstituted-1,2,4-triazoles derivatives were obtained from resin-bound acylhydrazines in several steps providing 78% - 87% overall yields and excellent purity. The advantages of this method include straightforward operation and high yield and purity of the products.