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N. A. Meanwell, J. L. Romine, M. J. Rosenfeld, S. W. Martin, A. K. Trehan, J. J. K. Wright, M. F. Malley, J. Z. Gougoutas, C. L. Brassard, J. O. Buchanan, M. E. Federic, J. S. Fleming, M. Gamberdella, K. S. Hartl, G. B. Zavoico and S. M. Seiler, “Nonprostanoid Prostacyclin Mimetics 5. Structure-Activity-Relationships Associated with [3-[4(4,5-Diphenyl-2-Oxazolyl)-5-Oxazolyl] Phenoxy] Acetic Acid,” Journal of Medicinal Chemistry, Vol. 36, No. 24, 1993, pp. 3884-3903. doi:10.1021/jm00076a018

has been cited by the following article:

• TITLE: Solid Phase Synthesis of 3,4,5-Trisubstituted-1,2,4-Triazoles Derivatives from the Resin-Bound Acylhydrazines

  AUTHORS: Rongjian Xie, Xingang Liu, Chao Mai, Zhanxiang Liu

  KEYWORDS: Resin-Bound Acylhydrazine; Solid-Phase Synthesis; 1, 2, 4-Triazoles

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.1A, April 30, 2013

  ABSTRACT: An extension of our methodology on solid-phase synthesis of 3,4,5-trisubstituted-1,2,4-triazoles under mild conditions has been developed. Firstly, the resin-bound acylhydrazine is reacted with orthoesters to provide resin-bound 1,3,4-oxadiazoles. Secondly, condensation of 1,3,4-oxadiazoles resin with the corresponding arylamines hydrochloride to form the the resin-bound triazoles. 3,4,5-Trisubstituted-1,2,4-triazoles derivatives were obtained from resin-bound acylhydrazines in several steps providing 78% - 87% overall yields and excellent purity. The advantages of this method include straightforward operation and high yield and purity of the products.