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C. Chen, R. Dagnino, C. Q. Huang, J. R. McCarthy and D. E. Grigoriadis, “1-Alkyl-3-Amino-5-Aryl-1H-[1,2,4]Triazoles: Novel Synthesis via Cyclization of N-Acyl-S-Methylisothioureas with Alkylhydrazines and Their Potent Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonist Activities,” Bioorganic & Medicinal Chemistry Letters, Vol. 11, No. 24, 2001, pp. 3165-3168. doi:10.1016/S0960-894X(01)00657-6

has been cited by the following article:

• TITLE: Solid Phase Synthesis of 3,4,5-Trisubstituted-1,2,4-Triazoles Derivatives from the Resin-Bound Acylhydrazines

  AUTHORS: Rongjian Xie, Xingang Liu, Chao Mai, Zhanxiang Liu

  KEYWORDS: Resin-Bound Acylhydrazine; Solid-Phase Synthesis; 1, 2, 4-Triazoles

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.1A, April 30, 2013

  ABSTRACT: An extension of our methodology on solid-phase synthesis of 3,4,5-trisubstituted-1,2,4-triazoles under mild conditions has been developed. Firstly, the resin-bound acylhydrazine is reacted with orthoesters to provide resin-bound 1,3,4-oxadiazoles. Secondly, condensation of 1,3,4-oxadiazoles resin with the corresponding arylamines hydrochloride to form the the resin-bound triazoles. 3,4,5-Trisubstituted-1,2,4-triazoles derivatives were obtained from resin-bound acylhydrazines in several steps providing 78% - 87% overall yields and excellent purity. The advantages of this method include straightforward operation and high yield and purity of the products.