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Rini, J.M., Schulze-Gahmen, U. and Wilson, I.A. (1992) Structural evidence for induced fit as a mechanism for antibody-antigen recognition. Science, 255, 959-965. doi:10.1126/science.1546293

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• TITLE: Theory of affinity maturation of antibodies

  AUTHORS: Udo Riss

  KEYWORDS: Affinity Maturation; Somatic Mutation; THz Waves; Antibody; Antigen

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.4 No.4A, April 30, 2013

  ABSTRACT: Based on the theory of long distance interaction between antibodies and antigens we developed a theory of affinity maturation of antibodies that is based on longitudinale electric waves. Early stage antibodies show a wide frequency spectrum for antigens and are polyspecific. After affinity maturation the antibody shows a very narrow band spectrum, the antibodies become monospecific. The feedback between antibody and antibody producing cell is done via messenger molecules that are also communicating with help of longitudinal electric waves. These messenger molecules transfer information from antibody arms and are informing cells whether the epitopes are switched on or off. The folding of antibody is done via eigen frequency resonances.