TITLE:
Polyphenolic extract association with renin inhibitors in experimental arterial hypertension
AUTHORS:
Manuela Ciocoiu, Magda Badescu, Oana Badulescu, Dana Tutunaru, Laurentiu Badescu
KEYWORDS:
Arterial Hypertension; Aliskiren; Aronia melanocarpa; Oxidative Stress
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.6 No.4,
April
29,
2013
ABSTRACT: Various
epidemiological studies have shown an inverse association between the
consumption of polyphenols or polyphenol-rich foods and the risk of cardiovascular
diseases. The purpose of the study was to emphasize the effects of the
association between the renin inhibitor and the polyphenolic extract on biochemical
parameters and systolic and diastolic blood pressure. The polyphenols are
extracted from isolated and purified vegetable material represented by the
mature fruit of the Aronia melanocarpa.
The experiment was performed on the arterial hypertension model. In the
arterial hypertensive model the cardioprotective effects of the polyphenolic
extract from Aronia melanocarpa are represented by the antioxidant,
hypocolesterolemiant intervention. Polyphenolic extract from Aronia melanocarpa reduce systolic and
diastolic arterial tension values in rats with drug-induced hypertension, a phenomenon more pronounced when
polyphenols are associated with Aliskiren (renin inhibitor). The combination
between the Aliskiren and polyphenolic extract produce superior hypolipidemic
and antioxidant effects than in the case of separate administration within
experimental arterial hypertension induced in the murine model.