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Lee-Hilz, Y.Y., Boerboom, A.M., Westphal, A.H., Berkel, W.J., Aarts, J.M. and Rietjens I.M. (2006) Pro-oxidant activity of flavonoids induces EpRE mediated gene expression. Chemical Research in Toxicology, 19, 1499-1505. doi:10.1021/tx060157q

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• TITLE: Polyphenolic extract association with renin inhibitors in experimental arterial hypertension

  AUTHORS: Manuela Ciocoiu, Magda Badescu, Oana Badulescu, Dana Tutunaru, Laurentiu Badescu

  KEYWORDS: Arterial Hypertension; Aliskiren; Aronia melanocarpa; Oxidative Stress

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.4, April 29, 2013

  ABSTRACT: Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of cardiovascular diseases. The purpose of the study was to emphasize the effects of the association between the renin inhibitor and the polyphenolic extract on biochemical parameters and systolic and diastolic blood pressure. The polyphenols are extracted from isolated and purified vegetable material represented by the mature fruit of the Aronia melanocarpa. The experiment was performed on the arterial hypertension model. In the arterial hypertensive model the cardioprotective effects of the polyphenolic extract from Aronia melanocarpa are represented by the antioxidant, hypocolesterolemiant intervention. Polyphenolic extract from Aronia melanocarpa reduce systolic and diastolic arterial tension values in rats with drug-induced hypertension, a phenomenon more pronounced when polyphenols are associated with Aliskiren (renin inhibitor). The combination between the Aliskiren and polyphenolic extract produce superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental arterial hypertension induced in the murine model.