TITLE:
Remotely activated, vibrational magnetoelastic array system for controlling cell adhesion
AUTHORS:
Steven Trierweiler, Hallie Holmes, Brandon Pereles, Rupak Rajachar, Keat Ghee Ong
KEYWORDS:
Cellular Adhesion; Vibration; Magnetoelastic Materials
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.6 No.4,
April
29,
2013
ABSTRACT: A
new system was designed to selectively control cellular adhesion to medical
implants. The system is based on magnetoelastic (ME) materials that can be
remotely set to generate mechanical vibrations at submicron levels with
predetermined amplitude and frequency. Previous studies have demonstrated the
capacity of these vibrations to control cellular adhesion at a substrate
surface. In this work, an ME film with two conjoined strips was developed to
investigate the potential of this system to provide region specific control
of cellular adhesion. In vitro cell culture experiments performed with L929
fibroblasts indicate that cellular adhesion can be increased or decreased at
different regions of the film by changing the frequency of the magnetic
field.