TITLE:
Association among Serum Organochlorine Pesticide Residues, Glutathione S-Transferase M1 Genetic Polymorphism and Female Breast Cancer
AUTHORS:
Jun Li, Shoufang Jiang, Yongli Chang, Zhong Guo, Sanqiao Yao, Juxiang Yuan, Guoli Li
KEYWORDS:
Breast Cancer; DDT; HCH; Glutathione S-Transferase M1 (GSTM1); Endocrine Disruptors; Gene Polymorphism; Interaction
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.2 No.2,
April
29,
2013
ABSTRACT: Background: The
purpose of this study was to evaluate the association
among serum organochlorine pesticide residues, glutathione S-transferase M1
genetic polymorphism and female breast cancer. Methods: A 1:1 matched
case-control study of 140 newly diagnosed breast cancer patients and 140
non-cancer female patients who consulted the five largest hospitals in the Tangshan
city from September 2006 to October
2007. Results: The result showed higher risk of breast cancer among
subjects with higher levels of serum DDT and HCH residue, the OR was 3.18 (95%CI, 1.11 - 9.07)
and 5.02 (95%CI, 1.64 - 16.56).The value of ORe associated with single environmental factor DDT high
residues, and ORg associated with single GSTM1 deletion genotype were respectively 3.86 (1.20 - 12.47)
and 1.34 (0.36 - 5.08). The OReg associated with combined action of two factors was 5.59 (1.63 - 18.90),
and the value of interaction parameters (γ) equaled 1.24. The value of ORe associated with single
environmental factor HCH higher residue and ORg associated with single GSTM1 deletion genotype were respectively 2.73 (0.84 - 8.87)
and 1.48 (0.49 - 4.60). The value of OReg associated with combined action of two factors was 3.87 (1.18 - 12.68),
and γ equaled 1.38. Conclusion: The
results indicated that breast cancer occurrence was the combined result of
environmental and genetic factors. The concurrent action of GSTM1 deletion
genotype and DDT/HCH enhanced the risk of breast cancer.