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S. Das, K. Pandey, A. Kumar, A. H. Sardar, B. Purkait, M. Kumar, S. Kumar, V. N. Ravidas, S. Roy, D. Singh and P. Das, “TGF-β1 Re-Programs TLR4 Signaling in L. donovani Infection: Enhancement of SHP-1 and UbiquitinEditing Enzyme A20,” Immunological Cell Biology, Vol. 90, No. 6, 2011, pp. 640-654. doi:10.1038/icb.2011.80

has been cited by the following article:

• TITLE: Down Regulation of MyD88 in Macrophages Treated with Liposomes Composed of Phosphatidylserine

  AUTHORS: Yuka Takasugi, Futoshi Kurai, Issei Kazume, Masaki Otsuka, Yoichi Negishi, Rui Tada, Yukihiko Aramaki

  KEYWORDS: Phosphatidylserine; Liposome; MyD88; TGF-β; Macrophage

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.4 No.2, April 28, 2013

  ABSTRACT: We have recently demonstrated that liposomes composed of phosphatidylserine (PS-liposomes) suppressed nitric oxide and inflammatory cytokine productions following LPS stimulation in macrophages. In this study, we examined the effect of PS-liposomes on expressions of TLR-4 and MyD88, which are essential for the signal transduction in LPS stimulation. Expression of MyD88 was suppressed when macrophages were treated with PS-liposomes, but not with liposomes of phosphatidylcholine. No change in TLR-4 expression was observed. MyD88 suppression was restored to the control levels when cells were pre-treated with anti-TGF-β antibody, suggesting that TGF-β plays an important role in down-regulation of MyD88 following PS-liposome treatment.