TITLE:
Biodegradable Chitosan/Multiwalled Carbon Nanotube Composite for Bone Tissue Engineering
AUTHORS:
Imelda Olivas-Armendariz, Santos Adriana Martel-Estrada, Mónica E. Mendoza-Duarte, Florinda Jiménez-Vega, Perla García-Casillas, Carlos A. Martínez-Pérez
KEYWORDS:
Bone Tissue Regeneration; Chitosan; Multiwalled Carbon Nanotubes; Composite
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.4 No.2,
April
28,
2013
ABSTRACT: In this work the influence
of multiwalled carbon nanotubes (MWCNT) on mechanical properties was evaluated
also the osteoinduction mechanism in Chitosan/MWCNT composite is reported. The
morphology and the mechanical properties of the scaffolds were controlled by varying
solvent ratios, quenching temperatures and carbon nanotubes concentration. In
vitro cell culture of Sprague-Dawley rat’s osteoblasts was used to evaluate the
phenotype expression of cells in the scaffolds. The presence of MWCNT in a
chitosan matrix improving its mechanical properties and sustain osteoblast
growth and differentiation that represent a potential application of the
Chitosan/MWCNT as biomaterial for bone tissue engineering.