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Black, H.R., Graff, A., Shute, D., Stoltz, R., Ruff, D. and Levine, J. (1997) Valsartan, a new angiotensin II antagonist for the treatment of essential hypertension: Efficacy, tolerability and safety compared to an angiotensin-converting enzyme inhibitor, lisinopril. Journal of Human Hypertension, 11, 483-489. doi:10.1038/sj.jhh.1000482

has been cited by the following article:

• TITLE: Radioiodination and biological evaluation of valsartan as a tracer for cardiovascular disorder detection

  AUTHORS: A. M. Amin, A. Abd El-bary, A. Abd El-Mohty, Shokry M. Saad, D. M. El-Sharawy

  KEYWORDS: Valsartan; Radioiodination; Cardiovascular Disorder Imaging

  JOURNAL NAME: Natural Science, Vol.5 No.4, April 26, 2013

  ABSTRACT: A procedure for radioiodination of valsartan with iodine-125 is carried out via an electrophilic substitution of hydrogen atom with the iodonium cation I+. All reaction parameters were studied to optimize the labeling conditions of valsartan and to obtain a maximum radiochemical yield (RCY) of the 125I-Valsartan [125I-Val]. By using 3.7 MBq of Na125I, 50 μg of valsartan (0.2 mM) as substrate, 25 μg of Iodogen (0.15 mM) as oxidizing agent in ethanol at room temperature for 30 min, the radiochemical yield of 125I-Val was 98.6% The radiochemical yield was determined by electrophoresis using cellulose acetate moistened with 0.02 M phosphate buffer pH 7. The labeled compound was separated and purified by means of high-pressure liquid chromatography (HPLC). The biological distribution in normal mice indicates the suitability of radioiodinated valsartan to image any cardiovascular disorders.