Article citationsMore>>

G. A. Somerville, M. S. Chaussee, C. I. Morgan, et al., “Staphylococcus aureus Aconitase Inactivation Unexpectedly Inhibits Post-Exponential-Phase Growth and Enhances Stationary-Phase Survival,” Infection and Immunity, Vol. 70, No. 11, 2002, pp. 6373-6382. doi:10.1128/IAI.70.11.6373-6382.2002

has been cited by the following article:

• TITLE: Neutrophilia-Inducing Deferoxamine in Mice Infected with Staphylococcus aureus

  AUTHORS: Mohemid M. Al-Jebouri, Nihad A. Jafar

  KEYWORDS: Neutrophilia; Deferoxamine; Gentamicin; S. aureus; Pathology

  JOURNAL NAME: Open Journal of Pathology, Vol.3 No.2, April 26, 2013

  ABSTRACT: The ability to sequester iron is a primary defense mechanism against bacterial infection. Iron chelation therapy has been considered as a possible treatment for various infectious diseases. S. aureus isolated from neonatal septicemia were used to study the effect of deferoxamine and sub-minimal inhibitory concentration of gentamicine on some virulence factors of this isolates. Also an experimental sepsis was inducted in mice and treated with gentamicin and deferoxamine. The expression of virulence factor (alpha-hemolysin, beta-hemolysin, delta-hemolysin, coagulase, and DNase) by Staphylococcusaureus isolates was significantly decreased (p S. aureus. In a murine model of S. aureus sepsis, deferoxamine treatment had an additional effect on survival and bacterial eradication from the organs of septicemic mice. In vitro exposure of S. aureus isolated to gentamicin and deferoxamine led to a decrease in the production of some virulence factors by these isolates.