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K. El-Haschimi, D. D. Pierroz, S. M. Hileman, C. Bjorbak and J. S. Flier, “Two Defects Contribute to Hypothalamic Leptin Resistance in Mice with Diet-Induced Obesity,” The Journal of Clinical Investigation, Vol. 105, No. 12, 2000, pp. 1827-1832. doi:10.1172/JCI9842

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• TITLE: The Role of Leptin in Cancer Pathogenesis

  AUTHORS: Ioannis Tourkantonis, Maria Kiagia, Evangelia Peponi, Sophia Tsagouli, Konstantinos N. Syrigos

  KEYWORDS: Leptin; Adipokines; Cancer; Systemic Inflammation

  JOURNAL NAME: Journal of Cancer Therapy, Vol.4 No.2, April 25, 2013

  ABSTRACT: Leptin is a hormone produced and secreted by adipose tissue. It is a member of adipokine family with a principal role in body weight regulation. It is reported that low brain leptin levels enhance the activity of hypothalamic orexigenic signals promoting feeding and suppressing energy expenditure and vice versa. Moreover, leptin via its three receptors participates in multiple neuroendocrine loops regulation. Serum leptin levels are positively associated with BMI (Body Mass Index) and whilst interact not only with other cytokines but also with serum insulin and cortisol levels. The aim of the present review is to study the role of leptin in carcinogenesis and its implications in cancer-related systemic inflammation.