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Strauer, B.E., Brehm, M., Zeus, T., Kostering, M., Hernández, A., Sorg, R., Kogler, G. and Wernet, P. (2002) Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation, 106, 1913-1918. doi:10.1161/01.CIR.0000034046.87607.1C

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• TITLE: Hematopoietic stem cells are a critical sub-population of whole bone marrow in the treatment of myocardial infarction

  AUTHORS: Philip Davy, Brienne Walker, Livingston Wong, Richard Allsopp

  KEYWORDS: Hematopoietic Stem Cells; Myocardial Infarction; Transplantation; Cardiac Disease

  JOURNAL NAME: Stem Cell Discovery, Vol.3 No.2, April 23, 2013

  ABSTRACT: Recent studies suggest that whole bone marrow (WBM) derived stem cells may facilitate recovery following myocardial infarction. However, the sub-population of WBM responsible for recovery remains uncertain. By adjusting the abundance of CD34+LinNeg cells in human bone marrow we examined the relative significance of hematopoietic stem cells (HSC) in the recovery of cardiac function in a murine model of induced myocardial infarction. Enrichment of HSC by ~100-fold in WBM transplanted into mice significantly increased recovery of heart function and reduced scar size compared to transplantation of WBM depleted in HSC by ~10-fold (P P P P