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Kamihata, H., Matsubara, H., Nishiue, T., Fujiyama, S., Tsutsumi, Y., Ozono, R., Masaki, H., Mori, Y., Iba, O., Tateishi, E., Kosaki, A., Shintani, S., Murohara, T., Imaizumi, T. and Iwasaka, T. (2001) Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation, 104, 1046-1052. doi:10.1161/hc3501.093817

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• TITLE: Hematopoietic stem cells are a critical sub-population of whole bone marrow in the treatment of myocardial infarction

  AUTHORS: Philip Davy, Brienne Walker, Livingston Wong, Richard Allsopp

  KEYWORDS: Hematopoietic Stem Cells; Myocardial Infarction; Transplantation; Cardiac Disease

  JOURNAL NAME: Stem Cell Discovery, Vol.3 No.2, April 23, 2013

  ABSTRACT: Recent studies suggest that whole bone marrow (WBM) derived stem cells may facilitate recovery following myocardial infarction. However, the sub-population of WBM responsible for recovery remains uncertain. By adjusting the abundance of CD34+LinNeg cells in human bone marrow we examined the relative significance of hematopoietic stem cells (HSC) in the recovery of cardiac function in a murine model of induced myocardial infarction. Enrichment of HSC by ~100-fold in WBM transplanted into mice significantly increased recovery of heart function and reduced scar size compared to transplantation of WBM depleted in HSC by ~10-fold (P P P P