TITLE:
Hematopoietic stem cells are a critical sub-population of whole bone marrow in the treatment of myocardial infarction
AUTHORS:
Philip Davy, Brienne Walker, Livingston Wong, Richard Allsopp
KEYWORDS:
Hematopoietic Stem Cells; Myocardial Infarction; Transplantation; Cardiac Disease
JOURNAL NAME:
Stem Cell Discovery,
Vol.3 No.2,
April
23,
2013
ABSTRACT: Recent studies suggest that whole bone
marrow (WBM) derived stem cells may facilitate recovery following myocardial
infarction. However, the sub-population of WBM responsible for recovery remains
uncertain. By adjusting the abundance of CD34+LinNeg cells in human bone marrow we examined the relative significance of hematopoietic
stem cells (HSC) in the recovery of cardiac function in a murine model of
induced myocardial infarction. Enrichment of HSC by ~100-fold in WBM
transplanted into mice significantly increased recovery of heart function and
reduced scar size compared to transplantation of WBM depleted in HSC by
~10-fold (P P P P