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Graham, D.J., Staffa, J.A., Shatin, D., Andrade, S.E., Schech, S.D., La Grenade, L., Gurwitz, J.H., Chan, K.A., Goodman, M.J. and Platt, R. (2004) Incidence of hospitalized rhabdomyolysis in patients treated with lipid- lowering drugs. Journal of the American Medical Association, 292, 2585-2590. doi:10.1001/jama.292.21.2585

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• TITLE: Fatty acids composition of erythrocytes in arterial hypertension associated with dyslipidemia

  AUTHORS: Tatyana P. Novgorodtseva, Yulia K. Karaman, Tatyana A. Gvozdenko, Marina V. Antonyuk, Vera V. Knyshova

  KEYWORDS: Fatty Acids; Arterial Hypertension; Dyslipidemia

  JOURNAL NAME: Health, Vol.5 No.4A, April 23, 2013

  ABSTRACT: Studied the fatty acid (FA) composition of erythrocyte membranes in patients with arterial hypertension associated with dyslipidemia. The fatty acid composition of erythrocyte membranes was studied by gaz chromatography. In all hypertensive patients are disturbed lipid FA composition of erythrocytes: increase in saturated fatty acids (15:0, 16:0), monoenic fatty acids (18:1n9, 18:1n7), polyunsaturated fatty acids (PUFA) family n6 (20:4n6), decrease in polyunsaturated fatty acids family n3:22:5n3, 22:6n3, the total value of n3 PUFA. Cells endogenous deficiency of n3 PUFA leads to the changes of the plasmatic membranes physicochemical properties, activation of eicosanoids synthesis with proinflammatory and vasoconstriction activity, the formation of the systemic inflammatory syndrome and conditions for the atherogenesis. Thus, structural and functional changes in erythrocyte membranes in hypertension developed as a part of the common systemic disorder of lipid metabolism.