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K. H. Jung, M. J. Choi, S. Hong, H. Lee, S. W. Hong, H. M. Zheng, H. S. Lee, S. Hong and S. S. Hong, “HS-116, a Novel Phosphatidylinositol 3-Kinase Inhibitor Induces Apoptosis and Suppresses Angiogenesis of Hepatocellular Carcinoma Through Inhibition of the PI3K/AKT/mTOR Pathway,” Cancer Letters, Vol. 316, No. 2, 2011, pp. 187-195. doi:10.1016/j.canlet.2011.10.037

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• TITLE: Huh-7 Human Liver Cancer Cells: A Model System to Understand Hepatocellular Carcinoma and Therapy

  AUTHORS: Anna C. Krelle, Arinze S. Okoli, George L. Mendz

  KEYWORDS: Huh-7 Cells; Hepatoma; Anti-Cancer Therapies

  JOURNAL NAME: Journal of Cancer Therapy, Vol.4 No.2, April 23, 2013

  ABSTRACT: In the last decades, the use of in vitro systems in liver research has grown exponentially. Important reasons promoting this work are the high throughput and ease of genetic manipulations afforded by these experiments relative to in vivo experiments. Thousands of investigations of hepatocellular carcinoma have been performed employing the human hepatoma Huh-7 cell line. The extensive body of knowledge produced attests to the importance and value of this in vitro cell system to study the characteristics of hepatomas and the potential of natural and synthetic compounds to prevent and eliminate this liver cancer. The necessarily brief summary provided here attempts to summarise some of the most recent achievements and limitations of investigations with Huh-7 cells and derivatives.