TITLE:
Myocardial Infarction and Intracerebral Hemorrhage in a Chinese Population: Relationship with Lipoproteins and Adipokines
AUTHORS:
Jessica Smith, Zhenjun Liu, Huiling Lu, Daowen Wang, Katherine Cianflone
KEYWORDS:
Myocardial Infarction, Intracerebral Hemorrhage, Acylation Stimulating Protein, Complement C3, Adiponectin
JOURNAL NAME:
Chinese Medicine,
Vol.1 No.3,
December
30,
2010
ABSTRACT: BACKGROUND: Adipokines and inflammatory factors play an important role in disease progression. Two cardiovascular diseases which have important contributions to mortality and morbidity in China are in-tracerebral hemorrhage (ICH) and myocardial infarction (MI). Acylation stimulating protein has been shown in North American populations to have strong associations with risk factors for MI. Complement C3 (C3) a component of the innate complement immune system is the precursor protein to ASP; C3 has been impli-cated in the pathogenesis of ICH. OBJECTIVE: In this case-control study we examined the association be-tween BMI, lipoproteins adiponectin, C3 and ASP) in a Chinese population. METHODS AND RESULTS: Three groups of subjects were studied: ICH group (N = 41), MI group (N = 60) and a control group (N = 44). There was no difference in BMI for either ICH or MI compared to controls (Control: 22.3 ± 0.3 kg/m2; ICH: 21.3 ± 0.4 vs MI: 22.5 ± 0.2, ICH and MI versus control pNS). The ICH group had lower LDL-C (Control: 3.21 ± 0.13 mmol/L; ICH: 2.54 ± 0.13; MI: 2.99 ± 0.13; ICH vs control p