TITLE:
Body temperature control in fever modeling after preliminary injection of glutamate receptors ligands into the solitary tract nucleus
AUTHORS:
Stanislav V. Koulchitsky, Svetlana G. Pashkevich, Nastassia M. Navasiolava, Marc-Antoine Custaud, Vladimir A. Kulchitsky
KEYWORDS:
Escherichia coli; Endotoxin; Brainstem; Fever; Control Body Temperature; Defense Reflexes
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.4,
April
19,
2013
ABSTRACT: Deep body temperature of 57
male Wistar rats was measured in response to systemic (i.v. or i.p.) injection of Escherichia coli lipopolysaccharide (LPS). Animals were preliminarily (4 weeks
before the experiment) treated with microinjections of the toxic dose of glutamate
receptors agonists or vehicle into solitary tract nucleus or caudal part of ventrolateral
medulla. Microinjections of the glutamate receptors agonists provoked a local destruction
of brain tissue, which was accompanied by the significant transformation (amplification or attenuation) of temperature response to the systemic injection of 3 μg/kg E. coli LPS. Animals treated with vehicle did not demonstrate significant changes
in their response to LPS. Obtained data testify that impairment of central nervous
structure involved in the regulation and maintenance
of deep body temperature is accompanied by atypical development of E. coli LPS-induced fever.