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Wells, C.A., Ravasi, T., Faulkner, G.J., Carninci, P., Okazaki, Y., Hayashizaki, Y., Sweet, M., Wainwright, B.J. and Hume, D.A. (2003) Genetic control of the innate immune response. BMC Immunology, 4, 5. doi:10.1186/1471-2172-4-5

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• TITLE: Tyrosine phosphorylation of monocyte-derived macrophage proteins in buffalo (Bubalus bubalis): A potential phenotype of natural resistance

  AUTHORS: Maria Miarelli, Federica Signorelli, Giovanna de Matteis

  KEYWORDS: Buffalo; Macrophage; Natural Resistance; Tyrosine Phosphorylation

  JOURNAL NAME: Open Journal of Animal Sciences, Vol.3 No.2, April 18, 2013

  ABSTRACT: The aim of this work was to explore the possibility of using the presence of tyrosine-phosphorylated macrophage proteins as a phenotype of natural resistance. Tyrosine-phosphorylation of macrophage proteins was investigated in 18 buffaloes, that carried either the resistant, or the non-resistant, Natural Resistance-Associated Macrophage Protein one (NRAMP1) genotype, that various authors have associated with susceptibility to intracellular bacterial diseases. Monocyte-derived macrophages were Interferon-gamma (IFN-γ) stimulated and tyrosine-phosphorylation was assessed by Western blotting. Evidence of phosphorylation after IFN-γ stimulation was shown by 75% of the buffaloes carriers of the resistant genotype, and by 20% of the carriers of the non-resistant genotype (Chisquare value between the groups = 5.44; P = 0.02). The study of the Proteoma of monocyte-derived macrophages might open the way to the genetic control of disease resistance.