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J. Schiedel, A. Blaukat, S. Li, et al., “Matuzumab Binding to EGFR Prevents the Confomational Rearrangement Required for Dimerization,” Cancer Cell, Vol. 13, No. 4, 2008, pp. 365-373.

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• TITLE: STYK1/NOK—A Potential Radiotherapeutic Target and Biomarker for Gastric Cancer and Cervical Cancer

  AUTHORS: Ling Gao, Xiaohua Chen, Zenghai Ma, Fengsheng Li

  KEYWORDS: Gastric Cancer; Cervical Cancer; STYK1/NOK; Therapeutic Target

  JOURNAL NAME: Journal of Cancer Therapy, Vol.4 No.2, April 17, 2013

  ABSTRACT: This article introduced the STYK1/NOK, including its origin, chemical composition and biological function, and the expression of STYK1/NOK in various cancer cell lines was reviewed. Furthermore, our recent study showed that STYK1/NOK protein was also over expressed in gastric cancer and cervical cancer specimens, and STYK1/NOK expression increased after tumor cells were irradiated with γ ray. These results indicated that STYK1/NOK might be involved in the occurrence and progress of gastric cancer and cervical cancer, and contribute to the radioresistance of tumor cells. Thus, STYK1/NOK might be a potential therapeutic target and diagnostic marker for gastric cancer and cervical cancer.