TITLE:
STYK1/NOK—A Potential Radiotherapeutic Target and Biomarker for Gastric Cancer and Cervical Cancer
AUTHORS:
Ling Gao, Xiaohua Chen, Zenghai Ma, Fengsheng Li
KEYWORDS:
Gastric Cancer; Cervical Cancer; STYK1/NOK; Therapeutic Target
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.2,
April
17,
2013
ABSTRACT: This article introduced the STYK1/NOK, including its origin, chemical composition and biological function, and the expression of STYK1/NOK in various cancer cell lines was reviewed. Furthermore, our recent study showed that STYK1/NOK protein was also over expressed in gastric cancer and cervical cancer specimens, and STYK1/NOK expression increased after tumor cells were irradiated with γ ray. These results indicated that STYK1/NOK might be involved in the occurrence and progress of gastric cancer and cervical cancer, and contribute to the radioresistance of tumor cells. Thus, STYK1/NOK might be a potential therapeutic target and diagnostic marker for gastric cancer and cervical cancer.