TITLE:
Effect of Calcium and Strontium on Mesoporous Titania Coatings for Implant Applications
AUTHORS:
Kathryn Grandfield, Shiuli Pujari, Marjam Ott, Håkan Engqvist, Wei Xia
KEYWORDS:
Mesoporous; Titania; Calcium; Strontium; Drug Delivery; Bone; EISA
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.4 No.2,
April
11,
2013
ABSTRACT: Increasing interest in the role of ions such as calcium and strontium in bone formation has called for the investigation of multifunctional ion-doped implant coatings. Mesoporous titania coatings incorporating calcium or strontium enabled a unique pore morphology and potential for drug delivery. Coatings were produced on titanium by an evaporation induced self-assembly method with the addition of calcium or strontium to the sol causing a shift in morphology from a hexagonally-packed to a worm-like porous network. Pore sizes ranged from 3.8 - 5 nm and coatings exhibited high surface areas between 181 - 215.5 m2/g, as measured by N2 adsorption-desorption. Coatings were loaded with 1 mg/ml Cephalothin, and showed sustained release of the antibiotic over one week in vitro. Cell studies confirmed that the ion addition had no toxic effect on human-like osteoblastic SaOS-2 cells. The results of this study suggest the potential for mesoporous coatings with calcium or strontium incorporation for direct bone-interfacing and combined drug delivery implant applications.