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H. A. Santos, J. Salonen, L. M. Bimbo, V. P. Lehto, L. Peltonen and J. Hirvonen, “Mesoporous Materials as Controlled Drug Delivery Formulations,” Journal of Drug Delivery Science and Technology, Vol. 21, No. 2, 2011, pp. 139-155.

has been cited by the following article:

• TITLE: Effect of Calcium and Strontium on Mesoporous Titania Coatings for Implant Applications

  AUTHORS: Kathryn Grandfield, Shiuli Pujari, Marjam Ott, Håkan Engqvist, Wei Xia

  KEYWORDS: Mesoporous; Titania; Calcium; Strontium; Drug Delivery; Bone; EISA

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.4 No.2, April 11, 2013

  ABSTRACT: Increasing interest in the role of ions such as calcium and strontium in bone formation has called for the investigation of multifunctional ion-doped implant coatings. Mesoporous titania coatings incorporating calcium or strontium enabled a unique pore morphology and potential for drug delivery. Coatings were produced on titanium by an evaporation induced self-assembly method with the addition of calcium or strontium to the sol causing a shift in morphology from a hexagonally-packed to a worm-like porous network. Pore sizes ranged from 3.8 - 5 nm and coatings exhibited high surface areas between 181 - 215.5 m2/g, as measured by N2 adsorption-desorption. Coatings were loaded with 1 mg/ml Cephalothin, and showed sustained release of the antibiotic over one week in vitro. Cell studies confirmed that the ion addition had no toxic effect on human-like osteoblastic SaOS-2 cells. The results of this study suggest the potential for mesoporous coatings with calcium or strontium incorporation for direct bone-interfacing and combined drug delivery implant applications.