TITLE:
Influence of magnetic iron oxide nanoparticles on red blood cells and Caco-2 cells
AUTHORS:
Daniel Moersdorf, Pierre Hugounenq, Lai Truonc Phuoc, Hind Mamlouk-Chaouachi, Delphine Felder-Flesch, Sylvie Begin-Colin, Geneviève Pourroy, Ingolf Bernhardt
KEYWORDS:
Red Blood Cells; Caco-2 Cells; Ca2+ Content; Intracellular PH; Magnetic Iron Oxide Nanoparticles
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.1 No.5,
December
30,
2010
ABSTRACT: The interactions of two types of cells (red blood cells, Caco-2 cells) with magnetic iron oxide nanoparticles (non-grafted, citrate-grafted, dendrimer-grafted) of 11 nm in size have been investigated. We focused on two important physiological parameters of the cells, the intracellular pH and the intracellular Ca2+ content. The results show that the nanoparticles do not have a significant influence on the pH and Ca2+ content of Caco-2 cells. The Ca2+ content of red blood cells is also not affected but the intracellular pH is slightly reduced.