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F. Herrmann, A. Lindemann, J. Gauss and R. Mertelsmann, “Cytokinestimulation of Prostaglandin Synthesis from Endogenous And Exogenous Arachidonic Acids in Polymorphonuclear Leukocytes Involving Activation and New Synthesis of Cyclooxygenase,” European Journal of Immunology, Vol. 20, No. 11, 1990, pp. 2513-2516. doi:10.1002/eji.1830201124

has been cited by the following article:

• TITLE: Synthesis of Some N-[(4-Substituted-1-Piperazinyl)-Oxo(Alkyl and Ethylcarbamoyl)]-3-(2-Thiophenyl)Acrylamides as Non-Steroidal Anti-Allergic and Anti-Inflammatory Agents

  AUTHORS: Osama I. Abd El-Salam, Ahmed M. Shalaby, Abdulah A. El-Sawy, Soha Elshihaby, Mohamed Abdulla

  KEYWORDS: Thiophene; Amino Acids; Piperazines; Anti-Allergy; Ant-Inflammatory

  JOURNAL NAME: Open Journal of Synthesis Theory and Applications, Vol.2 No.2, April 9, 2013

  ABSTRACT: An interesting approach for the design of anti-allergies is rationally considered. It was proved that current anti-allergic drugs comprise piperazine and acrylic acid segments. In harmony with these findings, new products 5a-u were synthesized starting from conjugated 2-thiopheneacrylic acid with amino acid esters3a-g followed by coupling of their acid derivatives4a-g with some piperazine segments, with the aim to increase their biological activities and decrease side effects. The anti-allergic and anti-inflammatory activities of the products were evaluated and promising results were obtained.